A humanoid creature can be afflicted with the curse of lycanthropy after being wounded by a lycanthrope, or if one or both of its parents are lycanthropes. A remove curse spell can rid an afflicted lycanthrope of the curse, but a natural born lycanthrope can be freed of the curse only with a wish. A lycanthrope can either resist its curse or embrace it... However, when the full moon rises, the curse becomes too strong to resist, transforming the individual into its beast form - or into a horrible hybrid form that combines animal and humanoid traits. When the moon wanes, the beast within can be controlled once again. Especially if the cursed creature is unaware of its condition, it might not remember the events of its transformation, though those memories often haunt a lycanthrope as bloody dreams.
[3] Many people believe that shifters are descended from lycanthropes, but [shifters believe] their abilities are a gift from Eberron or Lamannia, but… was corrupted by the daelkyr to create the curse of lycanthropy.
Whatever the [case], in the ninth century YK, the power of the curse surged…, and all lycanthropes were drawn toward evil. The Church of the Silver Flame engaged in a long crusade… all but eradicating lycanthropy from the Five Nations. The lycanthropes that survived hid in dark places, deep within the woods of the Eldeen Reaches and Droaam.
The common people of Khorvaire… don't understand that good-aligned lycanthropes exist.