SRD5:Disease

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D&D 5e (2014) SRD5 OGL CC-BY ʰ 

A plague ravages the kingdom, setting the adventurers on a quest to find a cure. An adventurer emerges from an ancient tomb, unopened for centuries, and soon finds herself suffering from a wasting illness. A warlock offends some dark power and contracts a strange affliction that spreads whenever he casts spells.

A simple outbreak might amount to little more than a small drain on party resources, curable by a casting of lesser restoration. A more complicated outbreak can form the basis of one or more adventures as characters search for a cure, stop the spread of the disease, and deal with the consequences.

A disease that does more than infect a few party members is primarily a plot device. The rules help describe the effects of the disease and how it can be cured, but the specifics of how a disease works aren’t bound by a common set of rules. Diseases can affect any creature, and a given illness might or might not pass from one race or kind of creature to another. A plague might affect only constructs or undead, or sweep through a halfling neighborhood but leave other races untouched. What matters is the story you want to tell.

End of the SRD5 material

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List of Diseases

14 diseases

Disease	Targets	Incubation	Primary Effects	Secondary Effects	Damage Type	Carriers	Deadly	Sources	Canon	Pointer	User Creation
Blinding Sickness	Target of spell	Immediate	pain, reduced Wis checks and saves	blindness			No	SRD-OGL v5.1	Yes	No	No
Bluerot	Humanoids	1-4 hours	boils, Con and Cha loss	fever, tingling extremities, water breathing	necrotic	undead	Yes	Ghosts of Saltmarsh	Yes	Yes	No
Burrowing Worms	Humanoids	1 turn	Necrotic damage	death and rise as the undead	necrotic	Spawns of Kyuss	Yes	Volo's Guide to Monsters	Yes	Yes	No
Cackle Fever	Humanoids	1-4 hours	fever, aches, exhaustion	laughter, incapacitation	psychic	Humanoids	Yes	SRD-OGL v5.1	Yes	No	No
Chaos Phage	Humanoids	None	Healing prevention, Hit Point Damage reduction, Death	Transformation into a Slaad		Blue Slaad	Yes	Monster Manual (5e)	Yes	Yes	No
Filth Fever	Target of spell	Immediate	fever	reduced Str checks, saves, and attack rolls			No	SRD-OGL v5.1	Yes	No	No
Flesh Rot	Target of spell	Immediate	flesh decay	decreased Cha checks, vulnerable to damage			No	SRD-OGL v5.1	Yes	No	No
Mindfire	Target of spell	Immediate	fever of the mind	decreased Int checks and saves, confusion			No	SRD-OGL v5.1	Yes	No	No
Red Face	beast, humanoid	1-4 days	reduced vision, itchy rash	blindness			No	Ghosts of Saltmarsh	Yes	Yes	No
Seizure	Target of spell	Immediate	shaking	decreased Dex checks, saves, and attack rolls			No	SRD-OGL v5.1	Yes	No	No
Sewer Plague	Humanoids	1-4 days	fatigue, cramps, exhaustion			rats, vermin, otyughs	Yes	SRD-OGL v5.1	Yes	No	No
Sight Rot	beast, humanoid	1-4 days	reduced vision	blindness			No	SRD-OGL v5.1	Yes	No	No
Slaad Egg	Humanoids	3 Months	Maturing into a Slaad Tadpole	Death		Red Slaad	Yes	Monster Manual (5e)	Yes	Yes	No
Slimy Doom	Target of spell	Immediate	bleeding	decreased Con checks and saves, stunned			No	SRD-OGL v5.1	Yes	No	No

Sources

• Wizards RPG Team. SRD-OGL v5.1 (5e 2014) (2015.05.06). Wizards of the Coast.

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