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A plague ravages the kingdom, setting the adventurers on a quest to find a cure. An adventurer emerges from an ancient tomb, unopened for centuries, and soon finds herself suffering from a wasting illness. A warlock offends some dark power and contracts a strange affliction that spreads whenever he casts spells.

A simple outbreak might amount to little more than a small drain on party resources, curable by a casting of lesser restoration. A more complicated outbreak can form the basis of one or more adventures as characters search for a cure, stop the spread of the disease, and deal with the consequences.

A disease that does more than infect a few party members is primarily a plot device. The rules help describe the effects of the disease and how it can be cured, but the specifics of how a disease works aren’t bound by a common set of rules. Diseases can affect any creature, and a given illness might or might not pass from one race or kind of creature to another. A plague might affect only constructs or undead, or sweep through a halfling neighborhood but leave other races untouched. What matters is the story you want to tell.

End of the SRD5 material

List of Diseases

13 diseases

Disease Targets Incubation Primary Effects Secondary Effects Damage Type Carriers Deadly Sources Canon Pointer User Creation
Blinding Sickness Target of spell Immediate pain, reduced Wis checks and saves blindness No SRD-OGL v5.1 Yes No No
Bluerot Humanoids 1-4 hours boils, Con and Cha loss fever, tingling extremities, water breathing necrotic undead Yes Ghosts of Saltmarsh Yes Yes No
Burrowing Worms Humanoids 1 turn Necrotic damage death and rise as the undead necrotic Spawns of Kyuss Yes Volo's Guide to Monsters Yes Yes No
Cackle Fever Humanoids 1-4 hours fever, aches, exhaustion laughter, incapacitation psychic Humanoids Yes SRD-OGL v5.1 Yes No No
Chaos Phage Humanoids None Healing prevention, Hit Point Damage reduction, Death Transformation into a Slaad Blue Slaad Yes Monster Manual (5e) Yes Yes No
Filth Fever Target of spell Immediate fever reduced Str checks, saves, and attack rolls No SRD-OGL v5.1 Yes No No
Flesh Rot Target of spell Immediate flesh decay decreased Cha checks, vulnerable to damage No SRD-OGL v5.1 Yes No No
Mindfire Target of spell Immediate fever of the mind decreased Int checks and saves, confusion No SRD-OGL v5.1 Yes No No
Seizure Target of spell Immediate shaking decreased Dex checks, saves, and attack rolls No SRD-OGL v5.1 Yes No No
Sewer Plague Humanoids 1-4 days fatigue, cramps, exhaustion rats, vermin, otyughs Yes SRD-OGL v5.1 Yes No No
Sight Rot beast, humanoid 1-4 days reduced vision blindness No SRD-OGL v5.1 Yes No No
Slaad Egg Humanoids 3 Months Maturing into a Slaad Tadpole Death Red Slaad Yes Monster Manual (5e) Yes Yes No
Slimy Doom Target of spell Immediate bleeding decreased Con checks and saves, stunned No SRD-OGL v5.1 Yes No No


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